![]() Additionally, blood clots form at regions of high shear stress within a blood vessel. These are needed for maintaining vascular cell functions such as nonthrombogenicity, regulation of blood flow, and vascular tone. Human umbilical vein endothelial cells (HUVECS), which form the lining of blood vessels, require a physiological shear stress to activate many vasoactive factors. Free-radical generation is suspected to play a key role in cardiovascular diseases.
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